Research & Development

Aarti Pharmalabs Limited (APL) has transformed from a vendor to a preferred partner. Our two cutting-edge R&D facilities, located in Gujarat's Dombivli and Vapi, consistently strive for:

  • Route Scouting and Design
  • New Product Development
  • Process Optimization and Scale-up
  • Life Cycle Technology Management

Establishing ourselves as a global pharma API and intermediates manufacturer in the pharmaceutical sector is our strategic objective. In the long haul, we want to further embrace open innovation and build a worthwhile, sustainable nutraceutical companies.

We are prepared to seize development possibilities and play a crucial part in establishing our presence in the international pharmaceuticals sector, supported by our knowledge, experience, technical prowess, and resources organisation.

Research & Development

Expertise in specific chemistry

APL has developed expertise in various chemistries and to name a few:

Plant Scale

  • Ammonolysis
  • Condensation
  • Chlorination
  • Denitrochlorination
  • Diazotization
  • Ethylation
  • Halex (Fluorination)
  • Hydrogenation
  • Nitration
  • Sulphonation

Lab Scale

  • Alkylation
  • Acetylation
  • Amino Acid Esterification
  • Aldol Condensation
  • Asymmetric Hydrogenation
  • Benzidine Rearrangement
  • Biocatalysis
  • Bromination/Sandmeyer
  • Butyl Lithium Reaction
  • Balz-Schiemann Reaction
  • Boron Chemistry
  • Carboxylation
  • Cynation
  • Cyclocondensation
  • Chichibabin Reaction
  • Chiral Chemistry (Implementation of enzymatic technology)
  • Dehydrogenation
  • Denitrochlorination
  • Diborane Reduction
  • Darzens Glycidic Ester Condensation
  • Darzens Glycidic Ester Condensation
  • Esterification
  • Epoxidation
  • Fluorination: KF, AHF, DHF and Balz Schiemann
  • Friedel Crafts Reaction
  • Flow reactor technology at commercial scale
  • Grignard's Reaction
  • Hydrogenation/Dehalogenation/Reductive amination
  • Hetero Diels Alder Reaction
  • Kolbe Schmitt Reaction
  • Knoevenagel Reaction
  • Methoxylation
  • Meerwein-Ponndorf-Verley Reduction
  • Michael Addition
  • Negishi Reaction
  • Oxidation
  • Oppenauer Oxidation
  • Organometallic Coupling
  • Grignard/Kumada/Suzuki
  • Phosphorylation
  • Phosgenation
  • Ring Alkylation and N-alkylation
  • Sulfonation
  • Silylation
  • Sandmeyer Reaction
  • Suzuki Coupling
  • Swern Oxidation
  • Skraup Reaction
  • Steroid Chemistry
  • Triphosgene Reactions
  • Ullmann Reaction
  • Vapour phase reaction:
  • Ammoxidation/Isomerisation
  • Vilsmeier-Haack Reaction
  • Wittig Reaction
  • Willgerodt Reaction

Analytical Capability

APL has a state-of-the-art analytical laboratory with an experienced and qualified team of scientists engaged in

  • Analytical Method Development, Calibration and Validation
  • Structural Identification and Elucidation
  • Impurity, Byproduct and Metabolite Isolation
  • Analytical Technology Transfer and Documentation
  • Stability Studies as per ICH guidelines

Typical infrastructure at the Analytical Development laboratory consists of specialised equipment such as HPLC, GC, LCMS, GCMS, Flash-Chromatography, ICP-MS, Particle Size Analyser, NMR and other equipment such as colourimetry, auto-titrator, stability chamber etc.

Research & Development

Process Chemistry
Capability and Infrastructure

State of the art synthesis State of the art synthesis and
process development laboratories
Process Chemistry Capability and Infrastructure With more than 20 PhDs and 80 postgraduate scientists

Process Chemistry Infrastructure

Reaction workstations are established to conduct various unit reactions


Based on the business requirement, a dedicated team of scientists develops certain strategic chemistries contributing towards multiple growth projects.
Following strategic chemistries are being developed

Our laboratories are equipped to perform the following reactions in continuous mode

  • Liquid-Liquid: Nitration, diazotization, Grignard, sulfonation
  • Gas-Liquid: Chlorine, hydrogen fluoride
  • Slurry type: All types of slurry reactions with fast kinetics
  • Heterogeneous catalysis: Suzuki Coupling, Isomerisation

Our sophisticated photo-reactors are used to develop photochemistry-related products in a short time.

Our ultra-modern fixed-bed reactors are used to develop various vapour-phase chemistries such as ammoxidation reaction, vapour-phase isomerisation and vapour-phase alkylation to name a few.

Process safety Studies

We emphasise creating procedures that are intrinsically secure. To enable such fundamentally safe process development, we have a cutting-edge Process Safety Laboratory and expertise besides the Process Chemistry lab.

Our Process Safety Laboratory consists of the following data generation capability and infrastructure.

There are essentially four major hazards in chemical processing:

Health and environmental hazards are identified through the in-house SDS generated through GHS compliant software.

The chemical reaction hazards that may be generated during the chemical processing/storage. The three major chemical reaction hazards are:

  1. Thermal instability of reactants, reactant mixtures and products (including any intermediates, residues, wastes, potential contaminants and by-products)
  2. Exothermic reactions which raise the temperature to produce decomposition reactions or violent boiling
  3. Gas evolution

A dedicated team equipped with advanced laboratory equipment conducts different process safety studies.

  1. Thermal stability studies using
    1. Differential scanning calorimeter - DSC
    2. Thermal Screening Unit - TSU
    3. Vent size packaging - VSP
  2. Exothermic Reaction Studies using
    1. Reaction Calorimeter - RC1 (Atmospheric and Hastelloy Pressure vessel)
  3. Gas Evolution and Vent Sizing Studies using
    1. Gas Evolution measurement apparatus along with reaction calorimeter
    2. Thermal Screening Unit - TSU
    3. Vent size packaging - VSP
  4. Chemical reaction Hazard assessment through
    1. Accelerating rate calorimeter-ARC

We carry out thermal stability tests and other fire and explosion tests especially for powder safety testing. For quick results of powder safety testing, we have also extensive tie ups with third-party service providers. The data from these tests is assessed in-house in our laboratories.

We are also building capabilities and infrastructure for fire and explosion hazards such as

  1. Minimum ignition energy-MIE
  2. Flash point

We undertake Hazop studies during the R&D process development to ensure our processes are inherently safe for commercialization

We have developed a Safety Data Sheet (SDS) database of all the GHS compliant products and chemicals being used at APL. This online database is readily accessible to all employees. We also have in-house capabilities to retrieve and generate new MSDS for development products. Being a ‘Responsible Care’ company, such capability of material safety management also helps in establishing product stewardship for existing and new products which helps our employees and customers to take appropriate action and care while handling our chemicals and products.

Waste Pre-treatment Studies

Our waste pre-treatment studies aim to reduce the environmental load at process design stage while targeting various environmentally important parameters such as:

  1. COD
  2. BOD
  3. TSS
  4. pH
  5. TDS
  6. Ammoniacal Nitrogen content
  1. Bromide content
  2. Chloride content
  3. Sulphate content
  4. Metal content

R&D Excellence

APL’s Intellectual Property (IP) framework comprises stringent terms for access control, information sharing and authorised disclosure. It is designed to ensure complete confidentiality of its processes and knowledge while meeting ISO 27001:2013 requirements.

The Knowledge Management team is equipped with databases and skills to effectively undertake chemical searches in the perspective of Freedom-to-Operate/Non-Infringed Process development.

This team also ensures efficient implementation and monitoring of ISO 27001:2013 (Integrity, Confidentiality and Availability) accreditation requirements.

At APL, we initiate every project in R&D through a programme management system to enable an efficient flow from new enquiry to commercialisation. It enables the deployment of suitable resources for various activities, ensuring a methodical execution and its evaluation. Unexpected contingencies are provisioned for, while any deviations are anticipated and mitigated on time. The process also helps us to generate and communicate the expected timelines of the project to the stakeholders effectively.