Intermediates

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Intermediates

The focus of our API manufacturers in India and global section is on the creation of customised processes, their scaling up, and efficient manufacturing. By signing confidentiality agreements with our clients, we impose stringent intellectual property protection on the services we offer. The objective is to give our clients a solid and dependable platform that will enable them to expedite their API development projects effectively and affordably.

For Intermediates Enquiries mail us on:
int@aartipharmalabs.com

Our range of Intermediate products
API Name Intermediate Name CAS No. Stage

Abemaciclib Intermediate

4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl- 1,3,2- dioxaborolan-2-yl)-1H-benzo[d] imidazole 1231930-37-2 R&D
5-(4-ethylpiperazin-1-yl methyl) pyridin-2-yl amine 1180132-17-5 R&D

Acalabrutinib Intermediate

(3-Chloropyrazin-2-yl) methanamine hydrochloride 939412-86-9 Commercial
(2S)-2-(8-amino-1-bromoimidazo[1,5-a] pyrazin-3-yl)-1-Pyrrolidine carboxylic acid phenyl methyl ester 1420478-88-1 Commercial
4-(Pyridin-2-yl-aminocarbonyl) benzene boronic acid 850568-25-1 Pilot
N-(Benzyloxy carbonyl)-L-Proline 1148-11-4 Commercial

Afatinib Intermediate

Trans 4-Dimethylamino crotonic acid hydrochloride 848133-35-7 Commercial

Apalutamide Intermediate

4-Amino-2-fluoro-N-methyl-benzamide 915087-25-1 Commercial

Apixaban Intermediate

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one 503615-03-0 Commercial
Chloro[(4-methoxy phenyl) hydrazono] acetic acid ethyl ester 27143-07-03 Commercial
1-(4-Amino phenyl)-3-morpholino-5,6-dihydropyridin- 2(1H)-one 1267610-26-3 Commercial
3-Morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5,6- dihyropyridin-2-(1H)-one 545445-44-1 Commercial

Azathioprine Intermediate

5-Chloro-1-methyl-4-nitro imidazole 4897-25-0 Commercial

Bazedoxifene Intermediate

3-Methyl-5-(Phenyl methoxy)-2-[(4-Phenyl methoxy) Phenyl]-1H-Indole 198479-63-9 Commercial
4-[2-(1-Azepanyl) ethoxy] Benzyl chloride hydrochloride 223251-25-6 Commercial

Benazepril Intermediate

3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 86499-96-9 Commercial
(S)-3-Amine-2,3,4,5-tetrahydro-2-oxo-1H-benzazepine -1 -acetic-2,2- dimethyl ethyl ester 109010-60-8 Commercial

Bosutinib Intermediate

2-(3-chloro propoxy)-1-methoxy-4-nitro benzene 92878-95-0 Commercial
2-cyano-N-(2,4-dichloro-5-methoxy phenyl) acetamide 846023-24-3 Commercial
2-Methoxy-5-nitro phenol 636-93-1 Pilot

Canagliflozin Intermediate

2-(5-Bromo-2-Methyl benzyl)-5-(4-fluoro phenyl) thiophene 1030825-20-7 Commercial
2-(4-Fluorophenyl)-5-(5-iodo methyl phenyl) methyl] thiophene 898566-17-1 Commercial
2,3,4,6-Tetrakis-O-trimethylsilyl-D-glucono-1,5-lactone 32384-65-9 Commercial

Dapagliflozin Intermediate

4-(5-bromo-2-chlorobenzyl) phenyl ethyl ether 461432-23-5 Commercial
(2S,3R,4R,5S,6R)-2-[4-choloro-3-(7-ethoxy benzyl) phenyl]-6-(hydro methyl)-2-ethoxy tetrahydro-2H-pyran-3,4,5-triol 2361307-84-6 R&D
(2S,3R,4R,5S,6R)-2-(Acetoxy methyl)-6-[4-chloro-3-(4- ethoxy benzyl) phenyl] tetrahydro-2H-pyran-3,4,5-triyl triacetate 461432-25-7 Pilot

Darolutamide Intermediate

2-Chloro-4-(1H-pyrazol-5-yl) benzo nitrile 1297537-37-1 R&D

Droxidopa Intermediate

(2S,3R)-3-(Benzo[d][1,3]Dioxol-5-yl)-2-(1,3-Dioxo Iso indolin-2-yl)-3-hydroxy propanoic acid 96561-34-1 R&D

Duloxetine Intermediate

(S)-3-Methyl amino-1-(2-thienyl)-1-propanol 116539-55-0 R&D

Edoxaban Intermediate

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c] pyridine-2-carboxylic Acid Hydrochloride 720720-96-7 R&D
tert-Butyl [(1R,2S,5S)-2-Amino-5-[(dimethylamino) carbonyl] cyclohexyl] carbamate 365998-36-3 R&D
Ethyl 2-((5-chloropyridin-2-yl) amino)-2-oxoacetate hydrochloride 1243308-37-3 R&D

Elagolix Intermediate

1-(2-Fluoro-6-(trifluoromethyl) benzyl)-6-methyl pyrimidine-2,4(1H,3H)-dione 830346-47-9 Commercial
5-Bromo-1-(2-fluoro-6-(trifluoromethyl) benzyl)-6-methyl pyrimidine-2, 4(1H, 3H)-dione 830346-48-0 Commercial
tert-butyl N-[(1R)-2-hydroxy-1-phenylethyl] carbamate 102089-74-7 Pilot
(2R)-2-[(tert-butoxy carbonyl)amino]-2-phenyl ethyl methane sulfonate 102089-75-8 Pilot

Eluxadoline Intermediate

(S)-2-(tert-butoxy carbonylamino)-3-(4-carbamoyl-2,6- dimethyl phenyl) propanoic acid 623950-02-7 Pilot
Boc-3-Iodo-L-alanine methyl ester 93267-04-0 Commercial

Empagliflozin Intermediate

(R)-(-)-3-Hydroxy tetrahydrofuran 86087-24-3 Commercial
(3S)-3-[4-[(5-bromo-2-chloro phenyl) methyl] phenoxy] tetrahydrofuran 915095-89-5 Commercial
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy}tetrahydro-furan 915095-94-2 Commercial
(R)-tetrahydrofuran-3-yl 4-methyl benzene sulfonate 219823-47-9 Commercial
2,3,4,6-Tetrakis-O-trimethylsilyl-D-glucono-1,5-lactone 32384-65-9 Commercial
(3S)-3-[4-[(5-bromo-2-chloro-phenyl) methyl] phenoxy] tetrahydrofuran 915095-89-5 Commercial

Enalapril Intermediate

N-[1-(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanine (ECPPA) 82717-96-2 R&D

Enzalutamide Intermediate

4-Bromo-2-fluoro-N-methyl-benzamide 749927-69-3 Commercial

Fluxotine Intermediate

3-Hydroxy-N-methyl-3-phenyl-propylamine 42142-52-9 Commercial

Ibrutinib Intermediate

(S)-BOC-3-hydroxy piperidine 143900-44-1 Pilot
3-(4-Phenoxy Phenyl)-1H-pyrazole [3,4-d] pyrimidin-4-amine 330786-24-8 Commercial
3-Amino-4-cyano-5-(4-phenoxy phenyl) pyrazole 3307920-70-6 Commercial
(R)-3-(4-Phenoxy phenyl)-1-(Piperidin-3-yl)-1H-pyrazolo [3,4-d]pyrimidin-4-amine 1022150-12-4 Commercial

Lacosamide Intermediate

(R)-N-Benzyl-2-(benzyloxy carbonyl)amino-3-hydroxy propionamide 219835-31-1 Commercial
(R)-2-((t-butoxy) carbonylamino)-3-methoxy propanoic acid 86123-95-7 Commercial

Larotrectinib Intermediate

(3S)-pyrrolidin-3-ol hydrochloride 122536-94-1 Pilot

Linezolid Intermediate

3-fluoro-4-morpholinylaniline 93246-53-8 R&D
(R)-[N-3-(3-fluoro-4-morpholiny phenyl)-2-oxo-5-oxazolidinyl] methyl methane sulfonate 174649-09-3 R&D

Lumacaftor Intermediate

3-tert-Butoxy carbonyl phenyl boronic acid 220210-56-0 Pilot

Miglustat Intermediate

2,3,4,6-tetra-O-benzyl-D-glucitol 14233-28-8 Pilot

Montelukast Intermediate

2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 142569-70-8 Commercial

Moxifloxacin Intermediate

(S,S)-2,8-Diazabicyclo[4.3.0] nonane 151213-42-2 Commercial

Niraparib Intermediate

3-(Methoxy carbonyl)-2-nitrobenzoic acid 138229-59-1 R&D
tert-butyl (3S)-3-(4-amino phenyl) piperidine-1-carboxylate 1171197-20-8 R&D

Olmesartan Intermediate

Ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-imidazole-5-carboxylate 144689-93-0 Pilot

Osimertinib Intermediate

4-Fluoro-2-methoxy-5-nitro aniline 1075705-01-9 Commercial
3-(2-Chloropyrimidin-4-yl)1-methyl indole 1032452-86-0 Pilot
N-(4-Fluoro-2-methoxy-5-nitro phenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine 1421372-94-2 R&D

Ozanimod Intermediate

(S)-1-amino-2,3-dihydro-1H-indene-4-carbonitrile hydrochloride 1306763-57-4 R&D

Palbociclib/Ribociclib Intermediate

Tert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5 Commercial

Perindopril Erbumine Intermediate

(2aS,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid (OCI) 80875-98-5 R&D

Perindopril Intermediate

Benzyl (2s,3as,7as)-Octahydro-1H-Indole-2-Carboxylate 4-Methyl benzene sulfonate 94062-52-9 Commercial
N-[(S)-1-Carbethoxy-1-butyl]-(S)-alanine 82834-12-6 Commercial

Quinapril Intermediate

(S)-1,2,3,4-Tetrahydro-3-isoquinoline carboxylic acid 74163-81-8 Commercial
1, 2, 3, 4-Tetrahydro-3-isoquinoline carboxylic acid phenyl methyl ester p-toluene sulphonic acid 77497-97-3 Commercial

Ramipril Intermediate

(2S,3aS,6aS)-octahydro-Cyclopenta[b]pyrrole-2-Carboxylate Hydrochloride 87269-87-2 Commercial

Ranolazine Intermediate

N-(2,6-Diphenyl methyl)-1-piperazine acetylamide 5294-61-1 Commercial
1-(2-Methoxy phenoxy)-2,3-epoxy propane 2210-74-4 Commercial

Relugolix Intermediate

Ethyl-4-bromomethyl-2-[N-(2, 6-difluorobenzyl)-N-ethoxycarbonylamino]-5-(4-nitrophenyl ) thiophene-3-carboxylate 308831-95-0 R&D
2-((2,6-difluorobenzyl)(ethoxy carbonyl)amino)-4- ((dimethylamino)methyl)-5-(4- nitro phenyl)thiophene-3-carboxylic acid 1589503-95-6 R&D

Rivaroxaban Intermediate

4-(4-Aminophenyl)morpholin-3-one 438056-69-0 R&D
(S)-2-(oxiran-2-ylmethyl) isoindoline-1,3-dione (or) (S)-Glycidyl Phthalimide 161596-47-0 R&D
5-Chlorothiophene-2-Carboxylic Acid 24065-33-6 R&D
2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl) phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione 446292-08-6 R&D

Rotigotine Intermediate

(S)-2-Amino-5-Methoxytetralin hydrochloride 58349-17-0 Commercial
(S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthal enamine Hydrochloride 93601-86-6 Commercial

Ticagrelor Intermediate

2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3 aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid 376608-65-0 R&D
4,6-dichloro-2-(propyl sulfanyl) pyrimidin-5-amine 145783-15-9 R&D
(1R, 2S)-2- (3,4-difluorophenyl) cyclopropanamine, HCl 1402222-66-5 Pilot

Tofacitinib Intermediate

(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1- amine (R)-2-hydroxy-2-phenylacetic acid salt 376608-71-8 R&D
4-Chloropyrrolo[2,3-d]pyrimidine 3680-69-1 Commercial

Tucatinib Intermediate

[1,2,4]Triazolo[1,5-a]pyridin-7-ol 1033810-70-6 R&D
4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methyl aniline 937263-71-3 Pilot

Upadacitinib Intermediate

2-bromo-5-(p-tolylsulfonyl) pyrrolo[2,3-b] pyrazine 1201186-54-0 Pilot
N-[5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3- b]pyrazin-2-yl]- 1201187-44-1 Pilot

Vardenafil Intermediate

2-(2-Ethoxyphenyl)-5-methyl-7-propyl-3H- imidazo[5,1-f][1,2,4]triazin-4-one 224789-21-3 Commercial

Venetoclax Intermediate

Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluoro benzoate 1235865-75-4 Commercial
3-Nitro-4-((tetrahydro-2H-pyran-4yl) Methylamino) benzene sulfonamide 1228779-96-1 Commercial
1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1- yl]methyl}piperazine Dihydrochloride/base 1628047-87-9/ 1228780-72-0 Commercial

Venlafaxine HCl Intermediate

1-[2-(Amino)-1-(4-Methoxyphenyl)ethyl] cyclohexanol Hydrochloride 130198-05- 9 Commercial

Vilazodone Intermediate

3-(4-chlorobutyl)-5-cyanoindol 143612-79-7 Pilot
Ethyl-5-Amino-1-Benzofuran-2-Carboxylate HCl 183288-42-8 Pilot

Vericiguat Intermediate

Ethyl 5-fluoro-1-(2-fluorobenzyl)-1H- pyrazolo [3,4-b]pyridine-3-carboxylate 1361232-72-5 R&D
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